Bayesian Safety Signal Detection

Upload adverse event reporting data from any source to detect disproportionate signals using Gamma-Poisson shrinkage.

Expected columns: product, event

Each row = one adverse event report.

Signal Detection Results

Global Patient Safety

A platform for pharmacovigilance signal detection across multiple international adverse event reporting systems.

Supported Data Sources

  • FAERS — FDA Adverse Event Reporting System (US drugs)
  • VAERS — Vaccine Adverse Event Reporting System (US vaccines)
  • MAUDE — FDA device reports
  • EudraVigilance — European Medicines Agency
  • VigiBase — WHO global ICSR database

Statistical Method

  • Prior: 2-component Gamma mixture fitted via EM algorithm
  • Posterior: full Gamma mixture with percentile-based signal detection
  • Reference: DuMouchel (1999), American Statistician 53(3)